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RAS Chemistry & Material ScienceКоординационная химия Russian Journal of Coordination Chemistry

  • ISSN (Print) 0132-344X
  • ISSN (Online) 3034-5499

Platinum dibromide complexes with 10-(aryl)phenoxarsines: synthesis, structure, luminescent and biological properties

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PII
S0132344X25020014-1
DOI
10.31857/S0132344X25020014
Publication type
Article
Status
Published
Authors
M. F. Galimova
  • Occupation: Arbuzov Institute of Organic and Physical Chemistry
  • Affiliation: Federal Research Center “Kazan Scientific Center of Russian Academy of Sciences”
Volume/ Edition
Volume 51 / Issue number 2
Pages
75-88
Abstract
The reactions of 10-(aryl)phenoxarsines (L1 = 10-(4-tolyl)phenoxarsine, L2 is 10-(4-fluorophenyl) phenoxarsine, L3 is 10-(3-fluorophenyl)phenoxarsine, and L4 is 10-(2-methoxyphenyl)phenoxarsine) with Pt(COD)Br2 afford platinum(II) complexes [Pt(L1–4)2Br2] (I–IV). The complexes are characterized by elemental analysis, IR spectroscopy, mass spectrometry, and NMR (1Н, 13С, 195Pt) spectroscopy. The Pt(II) complexes in solutions exist as two isomers mutually exchanging at a rate intermediate in the NMR time scale. The molecular structures of complexes cis-II · chloroform, trans-II, and cis-IV · dichloromethane are determined by XRD (CIF files CCDC nos. 2368769 (cis-II · chloroform), 2368770 (trans-II), and 2368771 (cis-IV · chloroform)). The platinum(II) dibromide complexes can crystallize as both cis and trans isomers. The study of the photophysical properties of the platinum(II) complexes shows that the trans isomers are characterized by emission in the orange spectral range, whereas the cis isomers almost does not luminesce. 10-(Aryl)phenoxarsines and their platinum(II) complexes are tested to cytotoxicity against the M-HeLa and HuTu 80 human cancer cell lines and hepatocyte-like cells of the Сhang liver line.
Keywords
феноксарсины комплексы платины(II) цис-транс-изомерия люминесценция цитотоксичность
Date of publication
14.09.2025
Year of publication
2025
Number of purchasers
0
Views
6

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